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Anti -2B4 Rabbit pAb

貨號:GB111427

品牌:Servicebio

價格:¥650

規格: 100 μl

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Product Information

 

Description 2B4 rabbit polyclonal
Protein full name Natural killer cell receptor 2B4
Synonyms NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2b4, Nmrk
Immunogen Recombinant protein corresponding to
Mouse 2B4
Isotype IgG
Purity Affinity purification
Predicted MW. 45 kDa
Observed MW. 60 kDa
Uniprot ID Q9BZW8, Q07763, Q9JLM2

 


 

Applications

 

Applications Species Dilution Positive Tissue
WB Human, Mouse, Rat 1: 500-1: 1000 lung, lymph node, spleen, thymus

 


 

Background

 

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.

     


 

Images

 

Western blot analysis of 2B4 (GB111427)
at dilution of 1: 1000
Lane 1: Jurkat cell lysate
Lane 2: Mouse lung tissue lysate
Lane 3: Mouse lymph node tissue lysate
Lane 4: Mouse spleen tissue lysate
Lane 5: Mouse thymus tissue lysate
Lane 6: Rat lung tissue lysate
Lane 7: Rat lymph node tissue lysate
Lane 8: Rat thymus tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

 

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